Tuesday, April 29, 2008

Maternal Ancestry of Malayalis - II

I have discussed about some of the maternal lineages of Malayalis before. At that time I didn't have any idea about my subclade. Recently, I came across a Jewish matrilineage data from yet to be published Doron M Behar's new study. I found my near match in one of the samples. That probably is a Malayali Jew lineage.


I have tested for HVRI and HVRII sequences and I have exact match in the following sequence.

EF556193 Haplogroup M
A73G T152C A263G 309.1C 315.1C G316A T489C A750G A1438G A4769G
T5201C C7028T A8701G T8843C A8860G A9180G T9540C G9947A A10398G C10400T
G10685A T10873C G11719A G12007A C12705T A13105G C14766T T14783C G15043A A15196G G15301A A15326G G15355A T15862C T15968C C16223T T16263C T16519C C16527T

My HVR sequence:

HVR1 : 16223T,16263C,16519C,16527T
HVR2 : 73G,152C,263G,309.1C,315.1C,316A,489C

I most likely belong to mtDNA haplogroup M4* as the complete sequence has mutation at location 12007.

M Derived: (HVR1 sequence)
M50* : 223, 263, 519 (*)

*Update 1-may-2008:
Behar et al. paper is out. I belong to mtDNA M50* subclade of macro haplogroup M4'30.

Update 10-May-2008:
Ibra has pointed out that the designation M50 has already been used in the study "Austro-Asiatic Tribes of Northeast India Provide Hitherto Missing Genetic Link between South and Southeast Asia", by Reddy et al. (2007). I appears Behar et al. are oblivious of this paper as they declare the designation is a new one. We can expect M50 getting a new name.

6 comments:

Ibra said...

Congratulations Manju! The mutation at location 12007 would have been the biggest hint. So what is the estimated frequency of M4 in that part Indian?

Manjunat said...

Thanks :-)!

I am not sure about the distribution. It appears 12007 has been rarely tested until now.

Ian Logan's database has some collection. I have many HVR1 matches all over India from Metspalu et al. 2004 database(pointed by you).

Manjunat said...

It appears 12007 has been rarely tested until now.

May be that's not the right way to put it. If a coding region full sequence is conducted 12007 would appear anyway. However, I haven't observed it in Metspalu et al. data base. I am not sure whether Geneticists would test for selective mutations when it comes to mtDNA as in Y-chromosome.

Maju said...

In regard to this, you may be interested in the latest paper on Jewish mtDNA ancestry all around the world (India included) by D.M. Behar et al. at PLOS ONE:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0002062

I did not see any M4 among either Mumbai or Cochin Jews (M5 is most frequent among these) but they have it clear anyhow that M clades (among others) are native introgressions.

Manjunat said...

Maju, I have updated the post.


I did not see any M4 among either Mumbai or Cochin Jews (M5 is most frequent among these)


M50 is the subclade of M4'30 (or M4 or M30).

but they have it clear anyhow that M clades (among others) are native introgressions.

I think that is just a gene flow and not an introgression :-).

Maju said...

I think that is just a gene flow and not an introgression :-).

Whatever. You are right surely but I actually took the term "introgression" from the paper. Anyhow, I also criticised the authors for their evident "Israeli mindset" (ignoring likely admixture when it's not a super-obvious thing, i.e. in all West Eurasia). The data is there anyhow.